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Decreasing Ageing affect on Memory October 15, 2010

Posted by zach in Health, Medicine, Neuroscience, Physiology.
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Have you recently misplaced your car keys and spent hours trying to find them? A resent article from Science Daily explains how misplacing your keys may be a thing of the past.  A promising new drug candidate is currently being developed at the  University of Edinburgh to reverse age-related memory loss.  The researchers have developed a compound that has improved cognitive function and memory in aging mice. This compound works by blocking an enzyme known as 11beta-HSD1.  As we age our body changes, with these changes comes changes in the concentration of the enzymes in our body.  The cause of these enzymatic changes is not fully known but it can be linked to physiological effects such as stress.

The aging enzyme

11beta-HSD1 is an enzyme that is found in the brain which can produce stress hormones such as the glucocorticoids.  When there are high levels of glucocorticoids in the brain negatively affect memory.  Therefore, if we can find a way to block 11beta-HSD1 we could increase our memory by decreasing the negative pressure on memory. The problem with blocking 11beta-HSD1 is that until now it hasn’t been possible to find a molecule that has a high specificity for blocking only 11beta-HSD1.  After ingesting a synthetic compound that blocks 11beta-HSD1,  mice show a dramatic increase in memory after only ten days.  The increase in memory was quantified by the time it took mice to complete a Y maze.

A burgeoning field of research

The research in the biomedical world is very concentrated on developing medicines that will reduce or even try to eliminate the effects of aging.  In the past I have blogged about how targets of rapamycin act as a master regulator for protein synthesis.  If we could find a drug to regulate that regulated TOR we could in turn regulate aspects of how our body ages.  Maybe some day we will have a set of anti-aging drugs that will allow us to combat all the negative effects that come with growing old.  If researchers can keep developing synthetic compounds to stop memory loss there may be a day when you will never forget where you misplaced your keys.

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